
CellChek®
CellChek Fundamentals
The Cornea
Cell Density & Morphology Changes
Endothelial Morphology Examples

Normal Endothelial Cell Density (ECD)
Normal ECD declines with age.

Low ECD
Low ECD is a risk factor for cataract and corneal surgeries that can be missed without the use of specular microscopy.

Polymegethism
Change from uniform cell sizes to variable cell sizes is an indication of distress to the endothelium.

Pleomorphism
Change from optimum hexagonal cell geometry to variable / compromised cell shapes.

Normal ECD with Polymegethism and Pleomorphism
Here the ECD is typical, but there are also large changes in morphology with high variance in cell area / sizes (pleomorphism) and a large number of non-hexagonal cell shapes (4, 5, 7 sided cells, i.e. pleomorphism).
Konan Medical is trusted to provide the most widely used specular microscopy – endothelial analysis tools for routine clinical practice, clinical trials, professional reading centers, and the world’s #1 eye bank system for qualification of donor corneal tissue.
This is not a coincidence, it has been and is continuously earned…only from Konan.
Konan CellChek Quick Tips
Konan CellChek system has long been the market leader for robust endothelial analysis. But it is the difficult cases where we really shine. Contact Konan to obtain a copy of CellChek “Quick Tips” for in-depth clinical pearls for assessment of your most challenging cases including those that are good images of bad corneas.
